Review: PreToxx Hangover Remedy

Review: PreToxx Hangover Remedy

PreToxx — now reformulated and repackaged since our 2009 review and featuring a capital T instead of a lowercase one — still has one great thing going for it: It’s a pill, so choking it down is easy.

Designed to be consumed before you drink, one PreToxx pill contains the following: Vitamins B1, B6, B12, and C, Prickly Pear Extract, Milk Thistle (these two are the new elements), and N-Acetyl L-Cysteine, a popular hangover remedy ingredient.

The directions indicate you should take two to four of these pills before you start drinking — and take one pill a day to “support a healthy liver.”

I tried PreToxx and found that generally I felt fine the next day, if a bit sluggish. The problem was more immediately after I took it. There’s no good way to explain it, but I felt weird while I was out. A little foggy in the head, with a funny taste in my mouth. I tried it twice with similar results each time.

Was this an allergy? A weird reaction to something in the supplement? Or something coincidental and unrelated? I’m not sure. Your mileage will certainly vary, but for me, the odd side effects outweighed any benefit received the following day.

C / $20 for 60 pills 

PreToxx Hangover Remedy




Christopher Null is the founder and editor in chief of Drinkhacker. A veteran writer and journalist, he also operates Null Media, a bespoke content creation company.


  1. Sean on February 12, 2011 at 9:20 pm

    My favorite quality of this product is the name,PreToxx, it’s pretty clever. I like the idea of taking a product to reduce or even eliminate a hangover, but to me it makes more sense to take a product that will give my body the antioxidants and minerals it needs to maintain optimal health and doubling up the days before and after I go out and destroy my body partying. Taking a high quality supplement on the regular keeps your body in prime form from a nutritional standpoint. If your body has what it needs to run efficiently, when you drink, your body will more effectively remove the toxins created, leaving you feeling much, much less hungover or not at all.

    Make sure you take a supplement that is good quality. Here is a blog post I found to decide what supplements to take, I hope it helps:

  2. John on September 28, 2011 at 7:42 am

    That sure sounds like an allergy to the product – perhaps one of the herbs (milk thistle or prickly pear) caused the symptoms you experienced? The other ingredients in PreToxx are substances found within all of us as they’re required by our bodies.

    We’ve gotten feedback that some experience drowsiness the next day, but it’s hard to determine if it’s due to the supplement or the late hours and drinking involved – definitely not to the degree that you experienced it. During most hangovers attention is usually taken away from your lack of sleep as it’s the pain that keeps you awake!

    Check out PreToxx on Amazon and you can read up on quite a few experiences with the supplement (including the ones from competitors pumping their own products). We’re the number one seller out of what’s likely 100+ hangover supplements out there today.

  3. Jamaal on May 8, 2015 at 7:57 pm

    Can someone review my product? It is called Hangover Counter Punch and I believe it is the best Hangover prevention/remedy supplement on the market.

  4. Michael on December 19, 2015 at 8:38 pm

    First time user. I just took three pills (as directed) 20 min ago. My face is itchy and there are ~6 small (a 1x1cm) red rashes on it. It freaked me a out a bit at first and then I remembered the pills, and well, here I am on this forum.

    This reaction is pretty ridiculous – why is this on the market?

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